Bile Salts - Intestinal Natural Detergents:
Bile acids are produced in the liver and secreted in the intestine
via the gall bladder. Bile acids are oxidation products of cholesterol.
First the cholesterol is converted to the trihydroxy derivative
containing three alcohol groups. The end of the alkane chain
at C # 17 is converted into an acid, and finally the amino acid,
glycine is bonded through an amide bond. The acid group on the
glycine is converted to a salt. The bile salt is called sodiumglycoholate.
Another salt can be made with a chemical called taurine.
The main function of bile salts is to act as a soap or detergent
in the digestive processes. The major action of a bile salt is
to emulsify fats and oils into smaller droplets. The various
enzymes can then break down the fats and oils.
QUES. Explain how bile salts work to emulsify fats. Talk about
the polar and non-polar parts of the molecule.